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Clinical Studies
Study 1

Davis, L.M., Coleman, C.D., Kiel, J., Rampolla, J., Hutchisen, T., Ford, L., Andersen, W.S., Hanlon-Mitola, A. (2010). Efficacy of a meal-replacement diet compared to a food-based diet after a period of weight loss and weight maintenance: a randomized controlled trial. Nutrition Journal, 9(11).

Objective

To examine the effect of Medifast’s meal-replacement program on body weight, body composition, and biomarkers of inflammation and oxidative stress among obese individuals following a period of weight loss and weight maintenance compared to an isocaloric, food-based diet.

Study 2

Cheskin, L.J., Mitchell, A.M., Jhaveri, A.D., Mitola, A.H., Davis, L.M., Lewis, R.A., Yep, M.A., Lycan, T.W. (2008). Efficacy of meal-replacements versus a standard food-based diet for weight loss in type 2 diabetes: a controlled clinical trial. The Diabetes Educator, 34(1), 118-127.

Objective

To compare the efficacy of a portion-controlled, meal-replacement diet to a standard diet (based on recommendations by the American Diabetes Association) in achieving and maintaining weight loss among obese men and women with type 2 diabetes mellitus.

Study 3

Haddock, C.K., Poston, W.S.C., Foreyt, J.P., DiBartolomeo, J.J. (2008). Effectiveness of Medifast supplements combined with obesity pharmacotherapy: a clinical program evaluation. Eating and Weight Disorders, 13(2), 95-101.

Objective

To evaluate the long-term impact of Medifast meal-replacement supplements (MMRS) combined with appetite suppressant medication (ASM) among participants who received 52 weeks of treatment as part of a medically supervised weight-control program.

Study 4

Davis, L.M., Coleman, C.D., Andersen, W.S., Cheskin, L.J. (2008). The effect of metabolism-boosting beverages on 24-hr energy expenditure. The Open Nutrition Journal, 2, 37-41.

Objective

To evaluate the effectiveness of thermogenic meal-replacement beverages (TMRB) containing 90 mg of epigallicocatechin gallate (EGCG) and 100 mg of caffeine on resting energy expenditure (REE), fat oxidation, and appetite.

Study 5

Matalon, V. (2000). An evaluation of weight loss following a carbohydrate- and fat-restricted diet with appetite suppressant and dietary supplementation. The Bariatrician, Summer, 10-13.

Objective

To assess the safety and effectiveness of a weight-loss regimen consisting of a carbohydrate- and fat-restricted diet supplemented with an appetite suppressant, a dietary supplement, and a liquid protein drink (Medifast) in an open label trial.

Study 6

Tchernof, A., Starling, R., Turner, A., Shuldiner, A.R., Watson, J.D., Silver, K., Poehlman, E.T. (2000). Impaired capacity to lose visceral adipose tissue during weight reduction in obese postmenopausal women with the Trp64Arg beta3-adrenoceptor gene variant. Diabetes, 49, 1709-1713.

Objective

To examine the effect of the Trp64Arg gene variant on total and visceral adipose tissue loss and cardiovascular risk factors in response to weight reduction among 24 obese women (age 57 ± four years) in a 13 ± three-month weight-reduction program of 1,200 kcal with or without the inclusion of Medifast.

Study 7

Coleman, C., Kiel, J., Davis, L.M., Mitola, A., Sonzone, C., (2012). Use of the Medifast meal replacement program for weight loss in overweight and obese clients: A retrospective chart review of three Medifast Weight Control Centers (MWCC). FASEB J. 26, lb327.

Objective

A chart review was performed to evaluate the effectiveness of the Medifast meal-replacement plan (MD) on body weight and body composition at 4, 12, 24 weeks (wk) and final weight-loss visit (19.6 ± 13.5 wk) (FV) at 3 MWCCs for the years 2007-10.

Study 8

Kiel, J., Coleman, C., Mitola, A., Sonzone, C., Davis, L.M., (2012). The impact of compliance on the effectiveness of the Medifast meal-replacement program for weight loss in overweight and obese clients: A retrospective chart review of three Medifast Weight Control Centers (MWCC). FASEB J. 26, lb398.

Objective

A chart review was performed to evaluate the association between compliance and the effectiveness of the Medifast meal replacement plan (MD) on body weight from baseline to final weight-loss visit (FV) at three Medifast Weight Control Centers (MWCC) for the years 2007-10.

Study 9

Yuh, J., Debrakeleer, D., McIntyre, W., Coleman C., Fox L., Barmat, L. (2011). Efficacy of a hypo caloric weight-management program in obese women with polycystic ovarian syndrome (PCOS) [abstract]. 9th Annual Meeting of Androgen Excess & PCOS Society; 2011 Oct 13 – 15, Abstract nr 21.

Objective

To evaluate the efficacy of a hypocaloric diet program utilizing a Health Coach on body weight and changes in biochemical and metabolic profiles in obese PCOS patients.

Study 10

Cheskin, L.J., Hanlon-Mitola, A., Mitchell, A., Jhaveri, A., Yep, M., Mitchell, V. (2007). A RCT comparing balanced energy deficit diets with or without meal replacements for weight loss and maintenance among children dieting. The Journal of the Federation of American Societies for Experimental Biology, 21, lb214.

Objective

To compare the safety and efficacy of supplemental Medifast portion-controlled meal replacements (MR) to a USDA Food Guide Pyramid-based diet (USDA) among children dieting alone or with a parent.

Study 11

Davis, L.M., Cheskin, L.J. (2006). Dietary intervention using Medifast meal replacements in prebariatric surgery patients: A statistical review of patient charts. Unpublished Data on File.

Objective

To evaluate the efficacy of a dietary intervention that included a reduced-calorie meal plan utilizing Medifast meal replacements, behavior counseling, and physical activity for achieving weight loss in low-income prebariatric surgery patients.

Study 12

Crowell, M.D., Cheskin, L.J., Musial, F. (1993). Multicenter evaluation of health benefits and weight loss on the Medifast weight-management program: a statistical review of patient charts. Unpublished Data on File.

Objective

To retrospectively evaluate the efficacy of a medically supervised, protein-supplemented modified program (Medifast) for weight reduction and to evaluate the impact of weight reduction on coexisting health problems.

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*Results will vary with effort. Take Shape For Life® believes that a Health Coach’s results will vary depending on his/her personal efforts and business structure.Take Shape For Life® does not guarantee any particular income level will be achieved. See Income Disclosure statement and Integrated Compensation Plan for complete details.